If you're going into the bush, tghe CDC recommends Hepatitus A & B, Tetnus, Polio, Typhoid and yellow fever. You can get then in a series at any travel clinic. If you haven't had Hep B, it takes a minimum of 6 months to complete the series.
There are a number of oral medications you can take for malaria, the most popular being malarone. We've taken malarone four times with no side effects, however, we're been on trips where people have had the side effect of a rash. Most people have no side effects, however, you should get your physician's recommendations.
Even if you're not necessarily going to use all the shots, get them. You never know where you're going to travel next.